
Disrupted geography from melting ice that affects hunting/searching patterns is one of the leading concerns. A study recently published in Biological Conservation estimated that in the Western Hudson Bay area, there is a 3-6% starvation rate for polar bears when there is a 120-day summer fasting period. But it is estimated that with an increase to a 180-day fasting period due to increased loss of summer sea ice, the starvation rate climbs dramatically to 28-48%.
Also, the report cited female reproductivity declining in a non-linear fashion (IE: a dramatic drop) when food searching efficiency decreases faster than sea ice habitats. In other words, it doesn't not take much in the way of a changing habitat to produce a major population crash.
Another effect of climate change and the influx of warmer waters into the Arctic is a greater exposure to parasites. A study in Polar Biology looked at the increasing prevalence of Taxoplasma gondii, a potentially deadly parasite, in polar bears and seals in Norway. It is not clear whether the parasite is being transmitted by warm water invertebrates, migratory birds, or human interactions - but climate changes can bring any or all of these potential carriers into play.

As stated in a Newswise release, "In later generations, the process begins to have more negative effects as genomes mix and any genes associated with environment-adapted traits are recombined. Genes related to any trait that once allowed the animal to thrive in a specific habitat can be diluted, leaving the animal less well suited to surviving and reproducing there."
As evidence, in 2006, hunters killed a polar bear with brown patches on its fur. DNA testing revealed it was a polar/grizzly bear hybrid. Such a hybrid, borne from polar and grizzly bear contact during the summer months, may have a very poor chance of survival in the Arctic winter months.
We like simple explanations to the challenges we face, but climate change has very complex and far-reaching implications. However, the more we learn about the impacts of climate change, the better we realize that it is a challenge we must address. That much is simple to comprehend.
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